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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 18.48
Human Site: S511 Identified Species: 25.42
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S511 L D S S T P N S F G A S K P C
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S511 L D S S T P N S F G A S K P C
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S632 L D S S T P N S F G A S K P C
Dog Lupus familis XP_543550 1017 111618 S511 L D S S T P N S F G A S K P S
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 F511 L D S S T P S F G A S K P C T
Rat Rattus norvegicus NP_001129232 1015 111665 F511 L D S S T P S F G A S K P C T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 N511 Q L M S L D S N A A N S L N T
Frog Xenopus laevis Q8QFR2 1013 112021 S511 L D S N T T S S S G A L K S N
Zebra Danio Brachydanio rerio XP_696478 1010 111223 R511 T A N S L G L R P S H D P S T
Tiger Blowfish Takifugu rubipres O42611 1025 111838 P511 D S S P G Q A P P L G L R P S
Fruit Fly Dros. melanogaster O17468 1047 113397 L508 L G R L D S R L K T Q P A S Q
Honey Bee Apis mellifera XP_001122939 838 91355 Q357 F T Q Q E L G Q P L D P A E Q
Nematode Worm Caenorhab. elegans Q09589 935 103412 K454 N E S K N S E K T M M E E R N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 Y483 S P V K Q R E Y R R P D G R K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 P511 L P A S A A A P A K G D S G D
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 I359 F D I A N K S I T D M S W N P
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 T509 L L V S S S G T G L S S L P Q
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 40 40 N.A. N.A. 13.3 53.3 6.6 13.3 6.6 0 6.6 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 53.3 53.3 N.A. N.A. 26.6 66.6 13.3 20 6.6 0 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 0 N.A. 13.3 13.3 26.6
P-Site Similarity: N.A. 0 N.A. 20 26.6 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 6 6 6 12 0 12 18 30 0 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 18 % C
% Asp: 6 48 0 0 6 6 0 0 0 6 6 18 0 0 6 % D
% Glu: 0 6 0 0 6 0 12 0 0 0 0 6 6 6 0 % E
% Phe: 12 0 0 0 0 0 0 12 24 0 0 0 0 0 0 % F
% Gly: 0 6 0 0 6 6 12 0 18 30 12 0 6 6 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % H
% Ile: 0 0 6 0 0 0 0 6 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 12 0 6 0 6 6 6 0 12 30 0 6 % K
% Leu: 59 12 0 6 12 6 6 6 0 18 0 12 12 0 0 % L
% Met: 0 0 6 0 0 0 0 0 0 6 12 0 0 0 0 % M
% Asn: 6 0 6 6 12 0 24 6 0 0 6 0 0 12 12 % N
% Pro: 0 12 0 6 0 36 0 12 18 0 6 12 18 36 6 % P
% Gln: 6 0 6 6 6 6 0 6 0 0 6 0 0 0 18 % Q
% Arg: 0 0 6 0 0 6 6 6 6 6 0 0 6 12 0 % R
% Ser: 6 6 53 59 6 18 30 30 6 6 18 42 6 18 12 % S
% Thr: 6 6 0 0 42 6 0 6 12 6 0 0 0 0 24 % T
% Val: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 % W
% Tyr: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _